Research work · 1973
Transplacental Passage of Erythromycin and Clindamycin
Agneta Philipson, L. D. Sabath, David Charles
New England Journal of Medicine
Abstract
PRESCRIBING antibiotics for pregnant women allergic to penicillin frequently presents a problem because of potential adverse effects — to mother or fetus — and uncertainty of transplacental delivery of antibiotic. Passage of drug into the fetus may or may not be desired.Erythromycin is a good alternative to penicillin for many infections, but it has been suggested that it does not reach the fetus in sufficient concentrations to prevent congenital syphilis.1 Little information on the transplacental passage of clindamycin, which has a spectrum of activity similar to that of erythromycin, is available. The present study was designed to demonstrate whether . . .