Research work · 2002

Microwave-Assisted Solid-Phase Synthesis of Peptoids

Hernando J. Olivos, Prasanna G. Alluri, M. Muralidhar Reddy, Derek Salony, Thomas J. Kodadek

Organic Letters

Abstract

Microwave irradiation reduces the reaction time for the solid-phase synthesis of peptoids. Under these conditions, coupling of each residue requires only 1 min. The purity and yields of peptoids synthesized in this way are as good as or better than those achieved using standard methods. [reaction: see text]

DOI: 10.1021/ol0267578