Research work · 2003
Gap junctions of bone cell and biophysical signals transductions
Huai Chen, 陈槐卿
Guoji shengwu yixue gongcheng zazhi
Abstract
Biomedical signals,especially mechanical loading plays an important role in the regulation of bone turnover.However,what is the mechanism and the downstream responses of bone cells to load induced signals is unclear.This review suggests that the gap junctional intercellular communication(GJIC) contributes to mechanotransduction in bone and to the regulation of bone cell differentiation by biophysical signals.Moreover,an implication of an integrated cell network essential for propagation of signals was indicated while biomaterial osteoblasts co culture is studied.