Research work · 2009
CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation
Cédric Auffray, Darin K. Fogg, Émilie Narni-Mancinelli, Brigitte Sénéchal, Céline Trouillet, Noah Saederup, Julia Leemput, Karine Bigot, Laura Campisi, Marc M. Abitbol, Thierry Jo Molina, Israel F. Charo
The Journal of Experimental Medicine
Abstract
CX(3)CR1 expression is associated with the commitment of CSF-1R(+) myeloid precursors to the macrophage/dendritic cell (DC) lineage. However, the relationship of the CSF-1R(+) CX(3)CR1(+) macrophage/DC precursor (MDP) with other DC precursors and the role of CX(3)CR1 in macrophage and DC development remain unclear. We show that MDPs give rise to conventional DCs (cDCs), plasmacytoid DCs (PDCs), and monocytes, including Gr1(+) inflammatory monocytes that differentiate into TipDCs during infection. CX(3)CR1 deficiency selectively impairs the recruitment of blood Gr1(+) monocytes in the spleen after transfer and during acute Listeria monocytogenes infection but does not affect the development of monocytes, cDCs, and PDCs.
DOI: 10.1084/jem.20081385